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The area has served as the long-time federal agency headquarters for cyber defense, software engineering, robotics, energy research and the nuclear navy. "Be it enacted by the Pennsylvania State Senate and Pennsylvania House of Representatives of the Commonwealth of Pennsylvania..the authority of the same, that the said town of Pittsburgh shall be...erected into a borough, which shall be called the borough of Pittsburgh for ever." The current pronunciation, which is extremely unusual in English speaking countries, is almost certainly a result of a printing error in some copies of the City Charter of March 18, 1816 (though not on the original document).
The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the Pittsburgh area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. The error was repeated commonly enough throughout the rest of the 19th century that the original pronunciation was lost and in 1890 the "h" was removed in order to make it easier to spell.
British General Edward Braddock was dispatched with Major George Washington as his aide to take Fort Duquesne.
The British and colonial force were defeated at Braddock's Field.
The disease spread into other areas, infected other tribes, and killed hundreds of thousands.
The French built Fort Duquesne based on La Salle's 1669 claims.
The French and Indian War, the North American front of the Seven Years' War, began with the future Pittsburgh as its center.
As of 2017, a total population of 305,704 lives within the city limits, making it the 63rd-largest city in the U. The metropolitan population of 2,353,045 is the largest in both the Ohio Valley and Appalachia, the second-largest in Pennsylvania (behind Philadelphia), and the 26th-largest in the U. Located at the confluence of the Allegheny, Monongahela, and Ohio rivers, Pittsburgh is known as both "the Steel City" for its more than 300 steel-related businesses, and as the "City of Bridges" for its 446 bridges.
The city features 30 skyscrapers, two inclined railways, a pre-revolutionary fortification and the Point State Park at the confluence of the rivers.
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A 1769 survey referenced the future city as the "Manor of Pittsburgh".